Possible explanation for the strong correlation between mRNA folding (mF) strength and protein abundance (PA). Possible explanation for the strong correlation.

Slides:

Advertisements

Similar presentations

Slide 1Fig. 15.1, p.453. Slide 2Fig. 15.1a, p.453.

Advertisements

Slide 1Fig. 11.1, p.337. Slide 2Fig. 11.2, p.338.

Slide 1Fig. 19.1, p Slide 2Fig. 19.2, p. 583.

Slide 1Fig. 21.1, p.641. Slide 2Fig. 21.2, p.642.

Inside of cell Interior of rough endoplasmic reticulum 5' Receptor protein Signal recognition particle mRNA Ribosome Signal sequence Protein synthesis.

P247. Figure 9-1 p248 Figure 9-2 p251 p251 Figure 9-3 p253.

Figure 1.1 The observer in the truck sees the ball move in a vertical path when thrown upward. (b) The Earth observer views the path of the ball as a parabola.

Slide 1Fig. 4.1, p.78. Slide 2Fig. 4.3, p.78 Slide 3Fig. 4.4, p.80.

Protein Synthesis Mrs. Harlin.

Protein Synthesis How to code for the correct amino acids.

Review of Protein Synthesis. Fig TRANSCRIPTION TRANSLATION DNA mRNA Ribosome Polypeptide (a) Bacterial cell Nuclear envelope TRANSCRIPTION RNA PROCESSING.

DNA encodes messenger RNA

The Genetic Code and Translation. Codon – three mRNA bases in a row that code for an amino acid Divide this mRNA strand into codons: AUGGGCACUCUCGCAUGA.

DNA, RNA, & Protein Synthesis (12.3) State Standards 2A. Distinguish between DNA and RNA. 2B. Explain the role of DNA in storing and transmitting cellular.

Information flow from DNA to trait

KikG structure (Protein Data Bank accession code 1XSS).

BTY100-Lec#4.2 DNA to Protein (Central Dogma).

Induction of mPer1 mRNA expression by prostaglandin E2 (PGE2) in NIH3T3 cells. Induction of mPer1 mRNA expression by prostaglandin E2 (PGE2) in NIH3T3.

Structures of CK1 inhibitors and their effects on CK1 activity in vitro. Structures of CK1 inhibitors and their effects on CK1 activity in vitro. (A) Structures.

Co‐localization of recombination proteins with double‐strand breaks.

Model for the involvement of Rep helicases as genome packaging motors.

What is your FICO IQ Quiz? Link to article attached.

'. \s\s I. '.. '... · \ \ \,, I.

IRES‐dependent translation is specifically abolished by an IRES point mutation. IRES‐dependent translation is specifically abolished by an IRES point mutation.

10-3 Protein Synthesis Together, all 3 types of RNA synthesize proteins. Proteins are polymers. Polypeptides linked by peptide bonds. Made of 20 different.

Mechanisms of lncRNA function.

Protein sequences and three‐dimensional structures of HUB1 (homologous to ubiquitin 1), ubiquitin and ubiquitin‐like modifiers. Protein sequences and three‐dimensional.

Yeast Tgl3p expressed in HeLa cells localizes to lipid droplets.

Yeast containing pICC10 (Tir) and pICC267 (CK18) and pTY474S and pICC267 demonstrated an approximately 12.5‐fold increase in β‐galactosidase activity compared.

SERCA2 is a functional adaptor for the alternative toll‐like receptor 9 (TLR9) signalling in cardiomyocytes Co‐immunoprecipitated TLR9 with SERCA2 antibody.

1,25‐dihydroxyvitamin D3 and retinoic acid induce p19ink4d expression.

Wild‐type p53 binds and represses Rad51 promoter.

Loss of OCTR‐1 signalling enhances the activation of XBP‐1‐mediated UPR pathway. Loss of OCTR‐1 signalling enhances the activation of XBP‐1‐mediated UPR.

Amino‐acid sequence of the heterogeneous nuclear RNP G protein family and RNA‐binding SELEX consensus sequence obtained for human RBMY. (A) Sequence alignment.

Data analysis of thermal proteome profiling

Multiple sequence alignment of the BAR domains from Amphiphysins and from the subset of BAR domain family members that were shown to bind to a small GTPase.

Identification of SERCA2 as a binding protein of toll‐like receptor 9 (TLR9) Representative image of tandem affinity purification visualized by silver.

Non‐specific activation of gene transcription by exogenous Fe65 in luciferase‐based reporter assays. Non‐specific activation of gene transcription by exogenous.

Protein Synthesis Translation.

NM1 localizes in nucleoli and is required for Pol I transcription.

Pathway analysis of direct interactions between selected nucleolar proteins, and other nuclear and cytoplasmic proteins. Pathway analysis of direct interactions.

The SE domains from BLM/Sgs1 orthologs show DNA SE activity.

Direct transcriptional regulation oflncRNAs by HIF AHeat map showing fold regulation by hypoxia and by the indicated HIF siRNA for lncRNAs adjacent to.

The mRNA stem cell signature.

Important modifying factors thought to impact the microbiome throughout life Important modifying factors thought to impact the microbiome throughout life.

Protein Synthesis Translation.

Buffering of non‐functional mRNA co‐regulation likely is a passive process Buffering of non‐functional mRNA co‐regulation likely is a passive process Percentage.

Correlating protein to mRNA and proteins per mRNA ratios

Identification of MOSPD2, a new FFAT motif‐binding protein

Clustering and geolocation of ocean samples based on SAR11 phylotype composition. Clustering and geolocation of ocean samples based on SAR11 phylotype.

' '· \ ·' ,,,,

The production of reduced or oxidized glutathione can occur at various stages during the formation of native disulphide bonds. The production of reduced.

The chloroplast 4.5S ribosomal RNA

Effect of mTOR inhibition on the Myc‐induced response

PERK activator treatment protects neurite network

Mechanism of Triton binding to ShHTL7

Mapping of small RNAs to LINE‐1 sequence (related to Figs 3 and 4)‏

Analysis of deep‐sequencing data obtained from the libraries of MILI‐bound piRNAs and total small RNAs (related to Fig 4)‏ Analysis of deep‐sequencing.

Examples for intrachromosomal mRNA co‐regulation patches

Correlation between DNA methylation and gene expression changes in T2D islets. Correlation between DNA methylation and gene expression changes in T2D islets.

HDAC1 positively regulates the abundance of miRNAs.

Resolution and quality of the cryo‐EM reconstructions

Comparison of proteomics and RNA‐Seq data.

Determination of mRNA synthesis and decay rates.

Examples of “Enrichment Analysis”

Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R cells to PORCN inhibition Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R.

Expression analysis of splicing factor mRNAs in various GBM datasets

Section 13.2 Protein Synthesis.

Joana Pinto Vieira, Julien Racle, Vassily Hatzimanikatis

Presentation transcript:

Possible explanation for the strong correlation between mRNA folding (mF) strength and protein abundance (PA). Possible explanation for the strong correlation between mRNA folding (mF) strength and protein abundance (PA). (A) Correlation between mF strength with ribosomal density (RD) and with the product of RD and mRNA levels. (B) Correlation between the mF strength of different segments of the coding sequence and PA (similar results were obtained for correlation with mean RD, and mean RD × mean mRNA levels—see supplementary Figs S1–S4 online). (C) There is no correlation between mF strength and mRNA half‐life (HL). (D) An illustration of a possible explanation for the relation between mF strength and PA. Hadas Zur, and Tamir Tuller EMBO Rep. 2012;13:272-277 © as stated in the article, figure or figure legend