Volume 132, Issue 2, Pages (February 2014)

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Volume 132, Issue 2, Pages 383-388 (February 2014) Application of the CellDetect® staining technique in diagnosis of human cervical cancer Song He, Gui-lan Wang, Yuan-yuan Zhu, Mei-hua Wu, Zhi-guo Ji, Juan Seng, Yi Ji, Jia-ming Zhou, Li Chen Gynecologic Oncology Volume 132, Issue 2, Pages 383-388 (February 2014) DOI: 10.1016/j.ygyno.2013.12.016 Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 1 Superficial squamous cells and endocervical cells stained by CellDetect®. (A1–3: conventional slides, B1–3: TCT slides, high magnification. CellDetect® staining, 400×). A1 B1: The cytoplasm stained in normal/atrophy/metaplasia superficial squamous cells was the vast majority blue/green. Nuclei staining was mostly blue/green or reddish/pink. A2 B2: In cell clusters, nuclei staining: mostly green/blue, cytoplasm staining: in the periphery, most cells had green/blue cytoplasm, in the center of the cluster, cells could have a pink/red cytoplasm. A3 B3: Cytoplasm and nuclei staining of endocervical cells: mostly intense red or violet. Gynecologic Oncology 2014 132, 383-388DOI: (10.1016/j.ygyno.2013.12.016) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 2 Atypical cells and SCC cells stained by CellDetect® (A1–2: conventional slides, B1–2: TCT slides, high magnification 400×). A1 B1: Low grade atypical cell nuclear enlargement with abnormal chromatin. Nuclei were stained in various shades of red. Cytoplasm stained mostly in pink/red or green (indicated by arrow). A2 B2: High grade atypical cells and SCC cells, which exhibited more nude nuclei with variation in nuclear size and shape, or with highly abnormal chromatin and enlarged, irregularly shaped macronucleoli. Nuclei and cytoplasm were stained in various shades of red and background erythrocytes were stained in green, neutrophil nuclei staining: mostly red, occasionally green/blue; cytoplasm staining: most green/blue (indicated by arrow). Gynecologic Oncology 2014 132, 383-388DOI: (10.1016/j.ygyno.2013.12.016) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 3 Morphology-color correlation analysis in different kinds of cells via CellDetect®. △: Normal group vs. inflammatory group, χ2=1.019, p>0.05; CIN 1–3 group Vs. SCC group, χ2=4.190, p>0.05; *: Normal and inflammatory groups vs. CIN1–3 and SCC groups, χ2=346.653, p=0.000. Gynecologic Oncology 2014 132, 383-388DOI: (10.1016/j.ygyno.2013.12.016) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 4 H&E and CellDetect® for pairs of adjacent sections from cervical biopsy tissues (A1–4: H&E staining; B1–4: CellDetect® staining) (200×). A1 B1: Normal cervical squamous epithelium; A2 B2: CIN 1; A3 B3: CIN 2–3; A4 B4: SCC. Gynecologic Oncology 2014 132, 383-388DOI: (10.1016/j.ygyno.2013.12.016) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 5 HE and CellDetect® for pairs of endocervical glands from cervical biopsy tissues (A1–2: HE; B1–2: CellDetect®; 200×). In CellDetect® staining, endocervical glands in stroma were stained in red or violet, the mucus secreted glands epithelial were stained in blue. Gynecologic Oncology 2014 132, 383-388DOI: (10.1016/j.ygyno.2013.12.016) Copyright © 2013 Elsevier Inc. Terms and Conditions