A Nurr1 Pathway for Neuroprotection Steven J. Bensinger, Peter Tontonoz  Cell  Volume 137, Issue 1, Pages 26-28 (April 2009) DOI: 10.1016/j.cell.2009.03.024 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 A Nurr1 Pathway for Transrepression of Inflammatory Gene Expression A model for Nurr1 transrepression based on the work of Saijo et al. (2009). (A) Inflammatory signals promote the expression of inflammatory genes through activation of NF-κB signaling and the recruitment of coactivator complexes, such as p300/CBP, by the NF-κB subunit p65 to inflammatory promoters. (B) In cells expressing Nurr1, such as microglia, inflammatory signals also trigger Nurr1 phosphorylation (by Nemo-like kinase; NLK) and sumoylation. This promotes its interaction with p65 leading to the recruitment of the CoREST complex to the promoters of inflammatory genes. Cell 2009 137, 26-28DOI: (10.1016/j.cell.2009.03.024) Copyright © 2009 Elsevier Inc. Terms and Conditions