Volume 171, Issue 2, Pages (October 2017)

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Volume 171, Issue 2, Pages 273-285 (October 2017) Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I. Bush, Marcus Conrad, Scott J. Dixon, Simone Fulda, Sergio Gascón, Stavroula K. Hatzios, Valerian E. Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E. Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C. Pagnussat, Jason Park, Qitao Ran, Craig S. Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M. Torti, Suzy V. Torti, Shinya Toyokuni, K.A. Woerpel, Donna D. Zhang Cell Volume 171, Issue 2, Pages 273-285 (October 2017) DOI: 10.1016/j.cell.2017.09.021 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 GPX4 Uses Glutathione to Eliminate Lipid Peroxides Formed in Phospholipids Containing Polyunsaturated Fatty Acids System xc− imports cystine, which is reduced to cysteine and used to synthesize glutathione, a necessary cofactor of GPX4 for eliminating lipid peroxides. Cell 2017 171, 273-285DOI: (10.1016/j.cell.2017.09.021) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Pathways Controlling Ferroptosis The indicated pathways regulate ferroptosis sensitivity. Cell 2017 171, 273-285DOI: (10.1016/j.cell.2017.09.021) Copyright © 2017 Elsevier Inc. Terms and Conditions