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ANCA disease: immunoserology and pathogenesis Alenka Vizjak Institute of Pathology · Faculty of Medicine University of Ljubljana, Ljubljana, Slovenia.

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ANCA disease: immunoserology and pathogenesis

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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.140 Figure 1 Historical landmarks of ANCA-testing in small vessel vasculitis Figure 1 | Historical landmarks of ANCA-testing in small vessel vasculitis. In the past 25 years, substantial progress has been made in the development of assays for detecting anti-neutrophil cytoplasmic antibodies (ANCAs). Achievements have been made in antigen characterization (indicated in green), in the standardization of ANCA assays (indicated in blue), in incorporation of ANCAs in nomenclature and classification proposals (indicated in pink) and in ANCA technology (indicated in grey). Consensus statements on ANCA testing are indicated in orange. In this timeline, the dates for the distinct assays formats concern the publications of commercially available immunoassays. CHCC, Chapel Hill Consensus Conference; C-ANCA, cytoplasmic ANCA staining pattern; ELISA, enzyme-linked immunosorbent assay; GPA, granulomatosis with polyangiitis; IIF, indirect immunofluorescence; MPO, myeloperoxidase; PR3, proteinase 3; P-ANCA, perinuclear ANCA staining pattern. Bossuyt, X. et al. (2017) Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.140