Figure 2 Monoamine synthesis and metabolism in neurons

Slides:

Advertisements

Similar presentations

Inborn Errors of Amino Acid Metabolism

Advertisements

A Window upon the Brain Analysis of CSF Neurotransmitters Cofactors and Vitamins John Earl Australasian Neurochemistry Laboratory Clinical Biochemistry.

Uppsala University PET Centre Per Hartvig, Uppsala University PET Centre Central dopaminergic and serotonergic function studied with positron emission.

Amino Acids Metabolism Amino Acids Metabolism 2 nd Year Medicine By Eman Mokbel Alissa, Ph.D.

Seven Amino Acids Are Degraded to Acetyl-CoA 1Dr. Nikhat Siddiqi.

Amino acid metabolism V. Enzymopathies related to amino acid metabolism Figures: Lehninger-4ed; chapter: 18 (Stryer-5ed; chapter: 23)

Individual amino acids metabolism of clinical importance ط Overview of synthesis of some important products of amino acids : Phenylalanine, Tyrosine, Tryptophane,

Inborn Errors of Amino Acid Metabolism (Renal Block) Biochemistry of: Phenylketonuria (PKU) Maple Syrup Urine Disease (MSUD) Albinism Homocyteinuria Alkaptonuria.

CONVERSION OF AMINO ACIDS TO SPECIALIZED PRODUCTS Jana Novotná.

Phenylketonuria Samuel Chan, Jekaterina Davydova PHM142 Fall 2015 Instructor: Dr. Jeffrey Henderson.

Neurotransmitters: Monoamines

Table 3 Limb-girdle muscular dystrophy standardized data collection form and HPO mapping Thompson, R. & Straub, V. et al. (2016) Limb-girdle muscular dystrophies.

Other markers of dopamine function in CSF and serum of RLS Karin Stiasny-Kolster Department of Neurology Philipps University Marburg Germany.

Inborn Errors of Amino Acid Metabolism

Date of download: 9/19/2016 Copyright © The American College of Cardiology. All rights reserved. From: Coronary endothelial dysfunction in the insulin-resistant.

One day or day one you decide ..

Eric Niederhoffer SIU-SOM

Conversion of Amino Acids to Specialized Products

Nat. Rev. Neurol. doi: /nrneurol

Lecture 2: Inborn Errors of aminoacid Metabolism

Synthesis and catabolism of dopamine and serotonin

Synthesis and catabolism of serotonin and the catecholamines

Chapter 7. Pharmacology and Biochemistry of Synaptic Transmission: Classical Transmitters Copyright © 2014 Elsevier Inc. All rights reserved.

Figure 3 Life expectancy at birth in all countries included

Figure 2 The US Centers for Disease Control and

Nat. Rev. Neurol. doi: /nrneurol

Clinical Use of CSF Neurotransmitters

Volume 75, Pages (October 2017)

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

The function of serotonin within the liver

Figure 19.1 Outline of entry of atmospheric nitrogen into the animal diet. PhotoDisc, Inc. Textbook of Biochemistry with Clinical Correlations, 7e edited.

Figure 4 Neuromyelitis optica spectrum disorder brain lesions

Figure 3 Metabolic configurations of M1 and M2 macrophages

Figure 1 Metabolic adaptations of cancer cells

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Physiological metabolism of Aβ in the brain and periphery

Figure 1 Schematic overview of the LGI1 protein in the synapse

Figure 2 Poststroke plasticity and recovery

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Principles of therapeutic ultrasound

Acetylcholine synthesis

Figure 1 Clinical correlates of neurodegeneration in MS

Figure 2 13C-octanoic acid gastric emptying breath test

Figure 3 Genetic pleiotropy in ALS

Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Nat. Rev. Neurol. doi: /nrneurol

Figure 3 Stroke-related deaths and DALYs by country development status

Figure 6 Vascular dysfunction in epilepsy

Adrenergic and Cholinergic Control in the Biology of Epidermis: Physiological and Clinical Significance Sergei A. Grando, Mark R. Pittelkow, Karin U.

Figure 6 Combining population-wide and high-risk strategies

Figure 3 Potential interplay between physiological

Nat. Rev. Neurol. doi: /nrneurol

Figure 2 Cellular pathways implicated in CIPN

Figure 6 Metabolism of pterins

Metabolic pathway changes of intracellular M. tuberculosis.

Figure 1 Timing of the effects of deep brain stimulation

Raymond T Bartus, Marc S Weinberg, R. Jude Samulski Molecular Therapy

Figure 1 A large number of genes are potentially associated with CIPN

Mammalian arginine metabolism pathway in macrophages.

Nat. Rev. Neurol. doi: /nrneurol

Balancing Act: Maintaining Amino Acid Levels in the Autistic Brain

Nat. Rev. Neurol. doi: /nrneurol

Mohammed Almannai, MD, Rana Felemban, MD, Mohammed A

Figure 4 NOS–NO pathway and therapeutic targets

Presentation transcript:

Figure 2 Monoamine synthesis and metabolism in neurons Figure 2 | Monoamine synthesis and metabolism in neurons. Tyrosine and tryptophan are the initial substrates in the synthesis pathway. Both substrates enter the brain via the large neutral amino acid transporter, and tyrosine is also produced in neurons by catabolism of phenylalanine. Levels of dopamine and serotonin metabolites can be measured in the cerebrospinal fluid and are crucial to the diagnosis of neurotransmitter disorders. Abbreviations: AADC, aromatic L-amino acid decarboxylase; BH2, dihydrobiopterin; BH4, tetrahydrobiopterin; DHPR, dihydropteridine reductase; PLP, pyridoxal 5′-phosphate; PTP, 6-pyruvoyl tetrahydrobiopterin; PTPS, PTP synthase; qBH2, quinoid BH2; VMAT2, vesicular monoamine transporter 2. Ng, J. et al. (2015) Monoamine neurotransmitter disorders—clinical advances and future perspectives Nat. Rev. Neurol. doi:10.1038/nrneurol.2015.172