Molecular Epidemiology Research and Training Program

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Presentation transcript:

Molecular Epidemiology Research and Training Program Major Focus: Environmental Exposures such as Smoking Molecular Genetic Alteration such as DNA Damage Gene-Environmental Interaction on Risk of Cancer

Introduction Established in 1975, Training 5 pre-doc and 2 post-doc fellows NCI Funded Training Program in Molecular Genetic Epidemiology of Cancer Directed by Dr. Zuo-Feng Zhang, and co-directed by Dr. Roger Detels. Offered by the Department of Epidemiology, UCLA School of Public Health Currently accepting applications for pre- (PhD) and post-doctoral positions.

Structure of T32 Training Program

Research Training Opportunities Methods in Genetic and Molecular Epidemiology Laboratory Training in Molecular Assays Molecular Studies of Smoking-related cancers (lung, oral, esophagus, liver, stomach, bladder) Molecular Studies of HIV-AIDS-related cancers (NHL, KS)

Cancer Molecular Epidemiology Studies Environmental Exposure and Cancer Genetic Molecular Markers and Susceptibility of Cancer Gene-Environmental Interaction on the risk of Cancer

Current Post-Doc Trainees Dr. Amy Lee Dr. Heather Tarleton

Current Pre-Doctoral Trainees Lani Park Sam Oh

Current Pre-Doc Trainees WANG, YI REN PECKHAM, ERIN CHRISTINE

Current Pre-Doc Trainees WALLAR, GINA MARIA NAEIM, BEHNAZ

G1 S G2 M P53 Cyclin D1 P16 Environmental Carcinogens / Procarcinogens Exposures PAHs, Xenobiotics, Arene, Alkine, etc Active carcinogens Detoxified carcinogens DNA Damage Normal cell Carcinogenesis Programmed cell death Tobacco consumption Occupational Exposures Environmental Exposure CYP1A1 GSTP1 mEH NQO1 XRCC1 GSTM1 2-1. Background: Theoretical model of gene-gene/environmental interaction pathway Ile105Val  Ala114Val Tyr113His His139Arg Pro187Ser MspI Ile462Val  Arg194Trp, Arg399Gln, Arg280His Null  Ala146Thr Arg72Pro G870A DNA damage repaired Defected DNA repair gene If DNA damage not repaired G0 If loose cell cycle control

Thank you very Much! If you have questions regarding to the possible training opportunity and application process please email your inquiry to zfzhang@ucla.edu UCLA is Equal Opportunity Employers, and minorities are encouraged to apply.