The Physiology and Pathophysiology of Vitamin D

Slides:

Advertisements

Similar presentations

Endocrine Regulation of Calcium and Phosphate Metabolism

Advertisements

CALCIUM AND PHOSPHATE HOMEOSTASIS. Organs: Parathyroid Four oval masses on posterior of thyroid gland Develops from the 3 rd and 4 th pharyngeal pouches.

My Treatment Approach to Hairy Cell Leukemia Rahul R. Naik, MD, Alan Saven, MD Mayo Clinic Proceedings Volume 87, Issue 1, Pages (January 2012) DOI:

Celebrating the Sesquicentennial of Mayo Clinic: 150 Years of Advances in Medical Practice, Education, Research, and Professionalism William L. Lanier,

The Physiology and Pathophysiology of Vitamin D

Negative feedback regulation of parathyroid hormone (PTH) release

Vitamin D metabolism and physiologic effects at target organs

Managing Cancer Pain: Basic Principles and Invasive Treatments

High Prevalence of Vitamin D Inadequacy and Implications for Health

Ductal Carcinoma in Situ of the Breast

Vitamin D Insufficiency

55-Year-Old Man With Anemia and Hemorrhagic Ascites

Ascites and Hepatorenal Syndrome: Pathophysiology and Management

Evaluation of Proteinuria

Diagnostic Options for Assessment of Postmenopausal Bleeding

William L. Lanier, MD Mayo Clinic Proceedings

Fibroblast Growth Factor 23 and CKD Prognosis

Treatment of Alcohol Withdrawal in Hospitalized Patients

Ayalew Tefferi, M.D. Mayo Clinic Proceedings

Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis

Michele A. Hanson, M.D., Daniel A. Dumesic, M.D.

Can Vitamin D Deficiency Break Your Heart?

High Prevalence of Vitamin D Inadequacy and Implications for Health

Ergocalciferol and Cholecalciferol in CKD

Palliative Care and Hospice Programs

Deep Venous Thrombosis of the Arm After Intravenous Immunoglobulin Infusion: Case Report and Literature Review of Intravenous Immunoglobulin-Related Thrombotic.

RICHARD K. WINKELMANN, M.D., Ph.D., J. CLARKE STEVENS, M.D.

Milk-Alkali Syndrome Mayo Clinic Proceedings

CHARLES H. DICKEN, M.D. Mayo Clinic Proceedings

Role of vitamin D in uterine fibroid biology

Evaluation and Management of Childhood and Adolescent Obesity

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications

Changing Incidence of Serum 25-Hydroxyvitamin D Values Above 50 ng/mL: A 10-Year Population-Based Study Daniel V. Dudenkov, MD, Barbara P. Yawn, MD,

Pancreatic Ductal Adenocarcinoma

2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation: Physiologic and Educational Rationale for Changes Roger D. White, MD Mayo.

Tally Naveh-Many, Justin Silver Kidney International

Graphic Interpretation of Serum Parathyroid Hormone, Calcium, and Phosphorus Values in Primary Hyperparathyroidism Pai C. Kao, Ph.D., Edward G. Lufkin,

MIGUEL A. VALDOVINOS, M. D. , MICHAEL CAMILLERI, M. D. , BRUCE R

Refurbishing Mayo Clinic Proceedings:

Vitamin D: The Iceberg Nutrient

Florian Lang, Michael Föller Kidney International

Antidepressants and Brain Neurochemistry

Venous Complications After Insertion of a Transvenous Pacemaker

Gastric Signet Ring Cell Carcinoma

Acquired Binocular Horizontal Diplopia

Metabolic Acidosis and Thiamine Deficiency

Renal Pyelocalyceal Squamous Cell Carcinoma

Osteoporosis Associated With Megestrol Acetate

The Blindness of John Milton

Evaluating the Patient With Diarrhea: A Case-Based Approach

Diabetic Mastopathy Mayo Clinic Proceedings

Hepatocellular Carcinoma

Pulmonary Tumor Embolism of Unknown Origin

Celebrating the Sesquicentennial of Mayo Clinic: 150 Years of Advances in Medical Practice, Education, Research, and Professionalism William L. Lanier,

Medical Treatment of Overactive Bladder: In Response

Mantle Cell Involvement of the Spleen

Volume 82, Issue 10, Pages (November 2012)

Organic Causes of Mania

Squamous Cell Carcinoma of the Tongue

Preoperative Smoking Cessation: The Role of the Primary Care Provider

Medical Student Distress: Causes, Consequences, and Proposed Solutions

Patient With Lethargy and Hypercalcemia

Ordering and Interpreting DNA Tests

Constrictive Pericarditis Due to Graft-vs-Host Disease

The ins and outs of phosphate homeostasis

Managing Cancer Pain: Basic Principles and Invasive Treatments

LINDA S. SNYDER, M.D., RUSSELL I. HEIGH, M.D., MONTE L. ANDERSON, M.D.

Hepatitis E in the United States: A Case of “Hog Fever”?

Volume 82, Issue 1, Pages (July 2012)

Managing the Complications of Cirrhosis

Presentation transcript:

The Physiology and Pathophysiology of Vitamin D MAURICE AUDRAN, M.D. Mayo Clinic Proceedings Volume 60, Issue 12, Pages 851-866 (December 1985) DOI: 10.1016/S0025-6196(12)64791-0 Copyright © 1985 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Formation of vitamin D3 in the skin. UV = ultraviolet. Mayo Clinic Proceedings 1985 60, 851-866DOI: (10.1016/S0025-6196(12)64791-0) Copyright © 1985 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Formation of 25-hydroxyvitamin D, in the liver. (From Kumar R: Metabolism of vitamin D. In Clinical Medicine. Vol 8. Chap 10. Edited by JA Spittell Jr. Philadelphia, Harper & Row, Publishers, 1982. By permission.) Mayo Clinic Proceedings 1985 60, 851-866DOI: (10.1016/S0025-6196(12)64791-0) Copyright © 1985 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 Formation of 1,25-dihydroxyvitamin D3 in the mitochondria of cells in the proximal tubule of the kidney. Ca = calcium; Nor = normal; Pi = inorganic phosphate. (From Kumar R: Metabolism of vitamin D. In Clinical Medicine. Vol 8. Chap 10. Edited by JA Spittell Jr. Philadelphia, Harper & Row, Publishers, 1982. By permission.) Mayo Clinic Proceedings 1985 60, 851-866DOI: (10.1016/S0025-6196(12)64791-0) Copyright © 1985 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 4 Physiologic defenses in hypocalcemia (left) and hypercalcemia (right). Ca = calcium; CT = calcitonin; 1,25-(OH)2D3 = 1,25-dihydroxyvitamin D3; 25(OH)D3 = 25-hydroxyvitamin D3; PTH = parathyroid hormone. Mayo Clinic Proceedings 1985 60, 851-866DOI: (10.1016/S0025-6196(12)64791-0) Copyright © 1985 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 5 Physiologic defenses in hypophosphatemia (left) and hyperphosphatemia (right). Ca = calcium; 25(OH)D3 = 25-hydroxyvitamin D3; Pi = inorganic phosphate; PTH = parathyroid hormone. Mayo Clinic Proceedings 1985 60, 851-866DOI: (10.1016/S0025-6196(12)64791-0) Copyright © 1985 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 6 Mechanism of action of 1,25dihydroxyvitamin D [1,25(OH)2D] in the intestinal cell. Ca = calcium; mRNA = messenger ribonucleic acid; Na = sodium. (From Kumar R: Metabolism of vitamin D. In Clinical Medicine. Vol 8. Chap 10. Edited by JA Spittell Jr. Philadelphia, Harper & Row, Publishers, 1982. By permission.) Mayo Clinic Proceedings 1985 60, 851-866DOI: (10.1016/S0025-6196(12)64791-0) Copyright © 1985 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 7 Metabolism of 1,25-dihydroxyvitamin D3. (From Kumar R.2 By permission of the American Physiological Society.) Mayo Clinic Proceedings 1985 60, 851-866DOI: (10.1016/S0025-6196(12)64791-0) Copyright © 1985 Mayo Foundation for Medical Education and Research Terms and Conditions