Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled.

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Presentation transcript:

Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials Faustino R. Pérez-López, M.D., Ph.D., Vinay Pasupuleti, M.D., Ph.D., Edward Mezones-Holguin, M.D., Vicente A. Benites-Zapata, M.D., Priyaleela Thota, M.D., Abhishek Deshpande, M.D., Ph.D., Adrian V. Hernandez, M.D., Ph.D. Fertility and Sterility Volume 103, Issue 5, Pages 1278-1288.e4 (May 2015) DOI: 10.1016/j.fertnstert.2015.02.019 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Flow diagram of selected studies. Fertility and Sterility 2015 103, 1278-1288.e4DOI: (10.1016/j.fertnstert.2015.02.019) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Meta-analyses of the effect of vitamin D intervention on primary outcomes (A) circulating 25-OHD; (B) preeclampsia; (C) gestational diabetes; (D) small for gestational age; (E) low birth weight; (F) preterm birth; (G) birth weight, and secondary outcomes (H) birth length; and (I) cesarean section. CI = confidence interval; D2 = supplement of vitamin D2; D3 = supplement of vitamin D3; df = degrees of freedom; high = higher dose; low = lower dose; M-H = Mantel-Haenszel; 25(OH)D = 25-hydroxyvitamin D3. Fertility and Sterility 2015 103, 1278-1288.e4DOI: (10.1016/j.fertnstert.2015.02.019) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Meta-analyses of the effect of vitamin D intervention on primary outcomes (A) circulating 25-OHD; (B) preeclampsia; (C) gestational diabetes; (D) small for gestational age; (E) low birth weight; (F) preterm birth; (G) birth weight, and secondary outcomes (H) birth length; and (I) cesarean section. CI = confidence interval; D2 = supplement of vitamin D2; D3 = supplement of vitamin D3; df = degrees of freedom; high = higher dose; low = lower dose; M-H = Mantel-Haenszel; 25(OH)D = 25-hydroxyvitamin D3. Fertility and Sterility 2015 103, 1278-1288.e4DOI: (10.1016/j.fertnstert.2015.02.019) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Meta-analyses of the effect of vitamin D intervention on primary outcomes (A) circulating 25-OHD; (B) preeclampsia; (C) gestational diabetes; (D) small for gestational age; (E) low birth weight; (F) preterm birth; (G) birth weight, and secondary outcomes (H) birth length; and (I) cesarean section. CI = confidence interval; D2 = supplement of vitamin D2; D3 = supplement of vitamin D3; df = degrees of freedom; high = higher dose; low = lower dose; M-H = Mantel-Haenszel; 25(OH)D = 25-hydroxyvitamin D3. Fertility and Sterility 2015 103, 1278-1288.e4DOI: (10.1016/j.fertnstert.2015.02.019) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions