Bone Imaging and Chronic Kidney Disease: Will High-Resolution Peripheral Tomography Improve Bone Evaluation and Therapeutic Management?  Justine Bacchetta, Stéphanie Boutroy, PhD, Laurent Juillard, MD, PhD, Nicolas Vilayphiou, Fitsum Guebre-Egziabher, MD, Solenne Pelletier, Pierre D. Delmas, MD, PhD, Denis Fouque, MD, PhD  Journal of Renal Nutrition  Volume 19, Issue 1, Pages 44-49 (January 2009) DOI: 10.1053/j.jrn.2008.10.023 Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Three-dimensional reconstruction, using HR-pQCT, of a tibia in a CKD patient. HR-pQCT, high-resolution peripheral quantitative computed tomography, CKD, chronic kidney disease. Journal of Renal Nutrition 2009 19, 44-49DOI: (10.1053/j.jrn.2008.10.023) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Distal tibia analysis with HR-pQCT. Qualitative alteration of cortical bone in two patients with CKD, from a homogeneous cortical bone (patient 1, A) to a heterogeneous cortical structure (patient 2, B). The two patients had no differences in terms of age, gender, GFR, drug exposure, parathyroid hormone, 25 OH vitamin D3, serum bicarbonate, total alkaline phosphatase, and hemoglobin. However, patient 1 suffered from interstitial nephritis, whereas patient 2 manifested hypertensive nephrosclerosis. Patient 2 had higher serum levels of cross-laps and osteocalcin (910 vs. 420 pg/mL and 60 vs. 23 μg/L, respectively). HR-pQCT, high-resolution peripheral quantitative computed tomography; CKD, chronic kidney disease; GFR, glomerular filtration rate. Journal of Renal Nutrition 2009 19, 44-49DOI: (10.1053/j.jrn.2008.10.023) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions