2003-2004 Antifungals 20 November 2018 12:58 AM.

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Presentation transcript:

2003-2004 Antifungals 20 November 2018 12:58 AM

Amphotericin B Antifungal Polyene antibiotic Binds to ergosterol and alters permeability Systemic

Inhibits synthesis of ergosterol Lanosterol 14a demethylase inhibitor Clotrimazole Imidazole antifungal Inhibits synthesis of ergosterol Lanosterol 14a demethylase inhibitor

Fluconazole Triazole antifungal Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

Converted by fungi to 5-fluorouracil  faulty RNA and DNA synthesis Flucytosine Antifungal Converted by fungi to 5-fluorouracil  faulty RNA and DNA synthesis

Griseofulvin Antifungal Binds to microtubules

Itraconazole Triazole antifungal Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

Ketoconazole Imidazole antifungal Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

Miconazole Imidazole antifungal Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

Nystatin Antifungal Polyene antibiotic Binds to ergosterol & alters permeability Topical

Terbinafine Allylamine antifungal Inhibits ergosterol synthesis by inhibiting squalene epoxidase

Voriconazole Triazole antifungal Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

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