Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study Dr Danish Saleheen, PhD,

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Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study Dr Danish Saleheen, PhD, Robert Scott, PhD, Sundas Javad, PhD, Wei Zhao, MS, Amrith Rodrigues, MS, Antonino Picataggi, BA, Daniya Lukmanova, MS, Megan L Mucksavage, MS, Robert Luben, PhD, Jeffery Billheimer, PhD, Prof John J P Kastelein, MD, S Matthijs Boekholdt, PhD, Prof Kay-Tee Khaw, PhD, Prof Nick Wareham, PhD, Prof Daniel J Rader, MD The Lancet Diabetes & Endocrinology Volume 3, Issue 7, Pages 507-513 (July 2015) DOI: 10.1016/S2213-8587(15)00126-6 Copyright © 2015 Saleheen et al. Open Acess article disrtibuted under the terms of CC BY-NC-ND Terms and Conditions

Figure 1 Cross-sectional correlates of cholesterol efflux capacity in control participants (n=1749) Assessed by linear regression analyses adjusted for age, sex, and batch number. From each fitted regression model, we obtained overall adjusted mean values and 95% CIs for cholesterol efflux capacity within quintiles of continuous markers, or within each category for categorical variables. SBP=systolic blood pressure. DBP=diastolic blood pressure. The Lancet Diabetes & Endocrinology 2015 3, 507-513DOI: (10.1016/S2213-8587(15)00126-6) Copyright © 2015 Saleheen et al. Open Acess article disrtibuted under the terms of CC BY-NC-ND Terms and Conditions

Figure 2 Association of cholesterol efflux capacity tertiles with incident coronary heart disease risk The Lancet Diabetes & Endocrinology 2015 3, 507-513DOI: (10.1016/S2213-8587(15)00126-6) Copyright © 2015 Saleheen et al. Open Acess article disrtibuted under the terms of CC BY-NC-ND Terms and Conditions

Figure 3 Association with coronary heart disease *Age, sex, history of diabetes, history of hypertension, cigarette use, alcohol intake, BMI, waist:hip ratio, LDL cholesterol concentration, log-triglyceride concentration. CEC=cholesterol efflux capacity. CHD=coronary heart disease. CVD=cardiovascular disease. The Lancet Diabetes & Endocrinology 2015 3, 507-513DOI: (10.1016/S2213-8587(15)00126-6) Copyright © 2015 Saleheen et al. Open Acess article disrtibuted under the terms of CC BY-NC-ND Terms and Conditions