RAI-Refractory Thyroid Cancer: Optimizing Treatment With Multikinase Inhibitors.

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Presentation transcript:

RAI-Refractory Thyroid Cancer: Optimizing Treatment With Multikinase Inhibitors

Case 1 Early 1993

Case 1 September 1993-January 2000

DTC Surveillance Strategies

Case 1 June-August 2000

RAI-Refractory DTC Definition

RAI-Refractory DTC Use of EBRT

Case 1 March 2002-December 2009

RAI-Refractory DTC Management Options and Considerations

RAI-Refractory DTC Sorafenib and Temsirolimus

Sorafenib Common AEs

RAI-Refractory DTC Second-Line Therapy

Sorafenib and Lenvatinib Phase 3 Pivotal Trials

DECISION Trial Outcomes

SELECT Trial Outcomes

Case 2 2007-2008

Case 2 2009-2010

Case 2 2011

Thyroid Cancer MAPK Pathway and Iodine Transport

Reversing RAI Refractoriness Selumetinib Trial

Case 2 May 2013-January 2014

Case 2 January 2014-March 2015

Abbreviations

Abbreviations (cont)

Abbreviations (cont)

References

References (cont)

References (cont)

References (cont)

References (cont)