A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella

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A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella Kyla S. Ost, June L. Round Immunity Volume 46, Issue 6, Pages 977-979 (June 2017) DOI: 10.1016/j.immuni.2017.06.010 Copyright © 2017 Terms and Conditions

Figure 1 A Microbiota Community That Promotes IFN-γ Production Suppresses Salmonella enterica Serovar Typhimurium Tissue Invasion and Disease (Left) Comparing S. typhirium (S. Tm) disease severity in genetically identical mice with differing microbiota communities revealed that communities that induce Th1 cell, Th17 cell, IL-17, and IFN-γ production reduce Salmonella (S. Tm) tissue invasion and disease. (Right) Transferring small communities of cultured bacteria from the resistant SPF2 community (red) to mice harboring the sensitive SPF1 community (blue) recapitulates this immune response and ameliorates Salmonella invasion. Immunity 2017 46, 977-979DOI: (10.1016/j.immuni.2017.06.010) Copyright © 2017 Terms and Conditions