Y. Huang, X.-F. Tian, X.-G. Fan, C.-Y. Fu, C. Zhu

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The pathological effect of Helicobacter pylori infection on liver tissues in mice Y. Huang, X.-F. Tian, X.-G. Fan, C.-Y. Fu, C. Zhu Clinical Microbiology and Infection Volume 15, Issue 9, Pages 843-849 (September 2009) DOI: 10.1111/j.1469-0691.2009.02719.x Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Gastric inflammation associated with Helicobacter pylori infection (haematoxylin and eosin staining). (a) Normal gastric musoca of uninfected animal. (b–d) Significant widespread lymphoplasmacytic gastritis of the entire mucosa and parts of the submucosa in the SS1-infected C57BL/6 mice. Original magnifications: x300 (a, b) and x600 (c, d). Arrows indicate infiltrating inflammatory cells in the mucosa and submucosal regions. Clinical Microbiology and Infection 2009 15, 843-849DOI: (10.1111/j.1469-0691.2009.02719.x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 C57BL/6 mouse liver tissue (haematoxylin and eosin, x300). (a) Focal hepatocyte necrosis with abundant lymphocyte, macrophage and neutrophil infiltration around the central vein. (b) Focal parenchymal inflammation with moderate lymphocyte and neutrophil infiltration and hepatocellular necrosis. (c) Mild inflammatory cell infiltration in periportal and perivenous areas. (d) Ballooning degeneration of hepatocytes. (e) Normal liver tissue of uninfected mice. Clinical Microbiology and Infection 2009 15, 843-849DOI: (10.1111/j.1469-0691.2009.02719.x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 Gall bladder mucosa of a Helicobacter pylori-infected C57BL/6 mouse (x300). (a) Normal gall bladder mucosa. (b) Thickening of mucous membrane with mild submucosal lymphocytic infiltration. Clinical Microbiology and Infection 2009 15, 843-849DOI: (10.1111/j.1469-0691.2009.02719.x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Helicobacter pylori staining in liver tissue of a C57BL/6 mouse (x600). (a) Carbol fuchsin staining. (b) Immunohistopathological staining. Clinical Microbiology and Infection 2009 15, 843-849DOI: (10.1111/j.1469-0691.2009.02719.x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions