The Cerebral Signature for Pain Perception and Its Modulation

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Presentation transcript:

The Cerebral Signature for Pain Perception and Its Modulation Irene Tracey, Patrick W. Mantyh Neuron Volume 55, Issue 3, Pages 377-391 (August 2007) DOI: 10.1016/j.neuron.2007.07.012 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Illustrating the Main Factors that Influence Nociceptive Inputs to Affect Pain Perception Neuron 2007 55, 377-391DOI: (10.1016/j.neuron.2007.07.012) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 2 Neuroanatomy of Pain Processing Main brain regions that activate during a painful experience, highlighted as bilaterally active but with increased activation on the contralateral hemisphere (orange). Neuron 2007 55, 377-391DOI: (10.1016/j.neuron.2007.07.012) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 3 The Descending Pain Modulatory System NCF (nucleus cuneiformis); PAG (periaqueductal gray); DLPT (dorsolateral pontine tegmentum); ACC (anterior cingulated cortex); +/− indicates both pro- and anti- nociceptive influences, respectively. Neuron 2007 55, 377-391DOI: (10.1016/j.neuron.2007.07.012) Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 4 Current Hypothesis Regarding the Central Role of the Descending Pain Modulatory System during Different Pain Experiences RVM (rostroventromedial medulla); PAG (periaqueductal gray); +/− indicates both pro- and anti- nociceptive influences, respectively. Neuron 2007 55, 377-391DOI: (10.1016/j.neuron.2007.07.012) Copyright © 2007 Elsevier Inc. Terms and Conditions