Risk of Serious Infections in Patients with Psoriasis on Biologic Therapies: A Systematic Review and Meta-Analysis Zenas Z.N. Yiu, Lesley S. Exton, Zarif.

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Risk of Serious Infections in Patients with Psoriasis on Biologic Therapies: A Systematic Review and Meta-Analysis Zenas Z.N. Yiu, Lesley S. Exton, Zarif Jabbar-Lopez, M. Firouz Mohd Mustapa, Eleanor J. Samarasekera, A. David Burden, Ruth Murphy, Caroline M. Owen, Richard Parslew, Vanessa Venning, Darren M. Ashcroft, Christopher E.M. Griffiths, Catherine H. Smith, Richard B. Warren Journal of Investigative Dermatology Volume 136, Issue 8, Pages 1584-1591 (August 2016) DOI: 10.1016/j.jid.2016.03.035 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Flow diagram showing the identification of literature in the PRISMA statement format. Journal of Investigative Dermatology 2016 136, 1584-1591DOI: (10.1016/j.jid.2016.03.035) Copyright © 2016 The Authors Terms and Conditions

Figure 2 Forest plot for dose-independent comparison between biologic therapies and placebo. Serious infection at week 12–16 for adults (randomized controlled trials). CI, confidence interval. Journal of Investigative Dermatology 2016 136, 1584-1591DOI: (10.1016/j.jid.2016.03.035) Copyright © 2016 The Authors Terms and Conditions

Figure 3 Forest plot for dose-independent comparison between biologic therapies and retinoid therapy/phototherapy. Serious infection in adults (cohort studies). CI, confidence interval; IV, inverse variance; SE, standard error. Journal of Investigative Dermatology 2016 136, 1584-1591DOI: (10.1016/j.jid.2016.03.035) Copyright © 2016 The Authors Terms and Conditions