Changes in the Clinical Impact of High-Risk Human Leukocyte Antigen Allele Mismatch Combinations on the Outcome of Unrelated Bone Marrow Transplantation

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Changes in the Clinical Impact of High-Risk Human Leukocyte Antigen Allele Mismatch Combinations on the Outcome of Unrelated Bone Marrow Transplantation Yoshinobu Kanda, Junya Kanda, Yoshiko Atsuta, Shigeo Fuji, Yoshinobu Maeda, Tastuo Ichinohe, Minoko Takanashi, Kazuteru Ohashi, Takahiro Fukuda, Koichi Miyamura, Takehiko Mori, Hiroshi Sao, Naoki Kobayashi, Koji Iwato, Akihisa Sawada, Shinichiro Mori Biology of Blood and Marrow Transplantation Volume 20, Issue 4, Pages 526-535 (April 2014) DOI: 10.1016/j.bbmt.2014.01.003 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 The cumulative incidence of grade III to IV acute GVHD grouped according to the HLA mismatch between the donor and recipient in the early (A), mid (B), and late time periods (C). HR-MM indicates high-risk mismatch; LR-MM, low-risk mismatch; MUD, matched unrelated donor. Biology of Blood and Marrow Transplantation 2014 20, 526-535DOI: (10.1016/j.bbmt.2014.01.003) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Overall survival grouped according to the HLA mismatch between the donor and recipient in the early (A), mid (B), and late time periods (C). The survival curves were adjusted for other significant factors by the mean of covariates method, in which average values of covariates are entered into the Cox proportional hazards model. HR-MM, high-risk mismatch; LR-MM, low-risk mismatch; MUD, matched unrelated donor. Biology of Blood and Marrow Transplantation 2014 20, 526-535DOI: (10.1016/j.bbmt.2014.01.003) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Adjusted overall survival (A,B) and the cumulative incidence of grade III to IV acute GVHD (C,D) grouped according to the underlying disease in the early time period. CML, chronic myelogenous leukemia; HR-MM, high-risk mismatch; LR-MM, low-risk mismatch; MUD, matched unrelated donor. Biology of Blood and Marrow Transplantation 2014 20, 526-535DOI: (10.1016/j.bbmt.2014.01.003) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 The cumulative incidence of grade III to IV acute GVHD (A) and adjusted overall survival (B) grouped according to the HLA mismatch loci between the donor and recipient in the mid or late time period. AB-HR MM, high-risk mismatch at the HLA-A or -B locus; C-HR MM, high-risk mismatch at the HLA-C locus; DR-HR MM, high-risk mismatch at the DRB1 locus; LR-MM, low-risk mismatch; MUD, matched unrelated donor. Biology of Blood and Marrow Transplantation 2014 20, 526-535DOI: (10.1016/j.bbmt.2014.01.003) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 The cumulative incidence of grade III to IV acute GVHD (A) and adjusted overall survival (B) grouped according to the HLA mismatch between the donor and recipient in the mid or late time period. 1HR-MM, 1 high-risk mismatch; 1LR-MM, 1 low-risk mismatch; 2LR-MM, 2 low-risk mismatches; 2MM with HR, 2 allele mismatches including at least 1 HR-MM. Biology of Blood and Marrow Transplantation 2014 20, 526-535DOI: (10.1016/j.bbmt.2014.01.003) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions