What does this protein make up or do? Chapter 1: Chromosome 1 DNA Sequence Chromosome 1228 bp Name of Protein 1 Name of Gene myocilin GLC1A transcription Amino acid sequence mRNA 490 aa translation Cytoplasm A Cell Nucleus What does this protein make up or do? may cause increased pressure in the eye by obstructing the aqueous outflow Condition/Disease Glaucoma

Description of Glaucoma Symptoms and characteristics Glaucoma is an eye disease in which the fluid pressure inside the eyes slowly rises, leading to loss of vision and/or blindness. At first, there are no symptoms If glaucoma remains untreated, people may miss objects to the side and out of the corner of their eye, progressing to tunnel vision and blindness. Glaucoma is detected through a comprehensive eye exam. Normal Vision As viewed by a person with glaucoma Pictures used with permission from URL: http://www.nei.nih.gov/health/glaucoma/glaucoma_facts.asp

Description of Glaucoma (cont.) Who is affected? Anyone, but the following have a higher risk: African Americans over the age of 40 Everyone over the age of 60, especially Mexican Americans People with a family history of glaucoma Outlook or quality of life With early treatment, eyes may be protected from serious vision loss Without treatment, individuals develop tunnel vision (only straight-ahead vision) and, over time, no vision (blindness). Treatments include medicine, laser procedure and/or surgery. There is no cure for glaucoma; Vision that is lost cannot be restored. Researcher: Jane Sample

References NCBI. Genes and Disease: Glaucoma [online]. 2003. [cited 2004 July 14]. Available at URL: http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.127. NCBI. Entrez [online]. 2003. [cited 2004 July 14]. Available at URL: http://www.ncbi.nih.gov/Entrez/. National Eye Institute. Glaucoma: What you should know [online]. 2004. [cited July 14]. Available at URL: http://www.nei.nih.gov/health/glaucoma/glaucoma_facts.asp.