Direct stenting limits sirolimus-eluting stent edge neointimal thickening Patrice Guérin, MD, PhD, Yann Gouëffic, MD, PhD, Marie-Françoise Heymann, MD,

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Direct stenting limits sirolimus-eluting stent edge neointimal thickening Patrice Guérin, MD, PhD, Yann Gouëffic, MD, PhD, Marie-Françoise Heymann, MD, Paul Pillet, MEng, Oussama Al Habash, MD, Dominique Crochet, MD, PhD, Pierre Pacaud, PhD, Gervaise Loirand, PhD Journal of Vascular Surgery Volume 46, Issue 2, Pages 354-359 (August 2007) DOI: 10.1016/j.jvs.2007.04.063 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 1 Effect of implantation of BMS and SES stent on RhoA and p27kip1 expression. Typical western blots and corresponding densitometric analyses of RhoA and p27kip1 expression in control arteries and in arteries stented with BMS or SES after a 28-day culture. BMS implantation did not modify RhoA expression (left) but induced a decrease in p27kip1 expression (right). In contrast, SES implantation induced a loss of RhoA expression associated with an increase in p27kip1 expression. Results were normalized to β-actin and expressed relative to that of day 0 as 1; *P < .001 BMS vs SES). Data shown are the mean of three to four independent experiments. Journal of Vascular Surgery 2007 46, 354-359DOI: (10.1016/j.jvs.2007.04.063) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 2 Neointimal thickening in stented arteries. A, Representative sections located in the edge or in-stent segment of arteries implanted with BMS (left) or SES (right) either after predilatation or direct stenting after a 28-day culture. L indicated the lumen, S the strut of the stent, and the asterisk the neointimal thickening. B, Quantification of neointimal thickening at the edge and inside the stent. BMS (left) and SES (right) have been implanted either after predilatation (black columns) or by direct stenting (empty columns) (*P < .03 and **P < .001). Journal of Vascular Surgery 2007 46, 354-359DOI: (10.1016/j.jvs.2007.04.063) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 3 Scanning electron microscopy of longitudinally cut stented arteries after 28 days of culture. Scanning electron microscopy demonstrated endothelial cell coverage of both BMS (A) and SES (B). Journal of Vascular Surgery 2007 46, 354-359DOI: (10.1016/j.jvs.2007.04.063) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions