Volume 67, Issue 3, Pages 569-576 (March 2015) Multifocality and Prostate Cancer Detection by Multiparametric Magnetic Resonance Imaging: Correlation with Whole-mount Histopathology  Jesse D. Le, Nelly Tan, Eugene Shkolyar, David Y. Lu, Lorna Kwan, Leonard S. Marks, Jiaoti Huang, Daniel J.A. Margolis, Steven S. Raman, Robert E. Reiter  European Urology  Volume 67, Issue 3, Pages 569-576 (March 2015) DOI: 10.1016/j.eururo.2014.08.079 Copyright © 2014 Terms and Conditions

Fig. 1 Results for a 62-yr-old male with intermediate-risk prostate cancer (biopsy Gleason score 4+3, prostate-specific antigen 11 ng/ml) and two high-suspicion regions of interest (image grade 4/5) at the mid-gland on multiparametric magnetic resonance imaging (MRI) performed with (A) T2-weighted imaging, (B) dynamic contrast-enhanced, and (C) diffusion-weighted imaging. (D) Both the left-sided index tumor (Gleason 3+4) and right-sided tumor (Gleason 3+3) observed on radical prostatectomy were detected by MRI; two additional small foci of Gleason 3+3 were missed. European Urology 2015 67, 569-576DOI: (10.1016/j.eururo.2014.08.079) Copyright © 2014 Terms and Conditions

Fig. 2 Rate of tumors detected and missed by multiparametric MRI, as stratified by maximal tumor diameter, Gleason score, index status, and tumor focality for all unique tumor foci (n=283). The index tumor is that with the highest Gleason score; if multiple foci had the same grade, the largest was considered the index lesion. European Urology 2015 67, 569-576DOI: (10.1016/j.eururo.2014.08.079) Copyright © 2014 Terms and Conditions

Fig. 3 Rate of tumors detected and missed by multiparametric magnetic resonance imaging, as stratified by maximal tumor diameter, Gleason score, and index status for solitary tumors (n=44, top) and multifocal tumors (n=239, bottom). European Urology 2015 67, 569-576DOI: (10.1016/j.eururo.2014.08.079) Copyright © 2014 Terms and Conditions