What does this protein make up or do? Chapter 10: Chromosome 10 DNA Sequence 419,014 Cadherin-23 Chromosome Name of Protein 10 Name of Gene CDH23 transcription 406 aa Amino acid sequence mRNA Cytoplasm translation It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A, Required for normal hearing. What does this protein make up or do? A Cell Nucleus Condition/Disease Usher Syndrome

Usher Syndrome Symptoms and characteristics There are three different types of the Usher Syndrome; type 1, type 2, and type 3. With type 1 Usher syndrome, Children are profoundly deaf at birth and have severe balance problems. With type 2 Children with Usher syndrome are born with moderate to severe hearing loss and normal balance. Children with type 3 Usher syndrome have normal hearing at birth. Some may develop balance problems later on. Hearing and sight worsen over time, but the rate at which they decline depends from person to person, even within the same family. Person with Usher syndrome (top) compared to a normal retina (bottom). http://www.nidcd.nih.gov/staticresources/health/hearing/images/retina0208.jpg

Description of Usher Syndrome (cont.) Who is affected? You can inherit it from your parents Someone who has inherited a change in the same gene from each parent Only carriers of the gene that carry the syndrome can be affected by the disease. Outlook or quality of life Depending on which type of Usher Syndrome you have (Type 1, 2, or 3) you may be born with deafness, or eventually be deaf and have decreased night vision, and may have balance problems (Especially with type 1 and 3). Usher syndrome affects hearing, balance, and vision. Researcher: AB

References "Usher Syndrome." Usher Syndrome. N.p., n.d. Web. 03 Mar. 2015. http://www.nidcd.nih.gov/health/hearing/pages/ush er.aspx#a "CDH23 Protien [Homo Sapiens]." NCBI. N.p., n.d. Web. 3 Mar. 2015. http://www.ncbi.nlm.nih.gov/protein/AAI39904.1 "Function." CDH23. Nextprot.org, n.d. Web. 03 Mar. 2015. http://www.nextprot.org/db/entry/NX_Q9H251