Volume 15, Issue 5, Pages (May 2012)

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Presentation transcript:

Volume 15, Issue 5, Pages 606-614 (May 2012) Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance Christopher B. Newgard Cell Metabolism Volume 15, Issue 5, Pages 606-614 (May 2012) DOI: 10.1016/j.cmet.2012.01.024 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Pathways of Branched-Chain Amino Acid Catabolism Shown in blue are the reactions that produce metabolites found in the BCAA-related principal component that associates with insulin resistance and other metabolic diseases. Cell Metabolism 2012 15, 606-614DOI: (10.1016/j.cmet.2012.01.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 2 Acylcarnitines in Skeletal Muscle in Rats Fed on Various Diets for 12 Weeks SC, standard chow; SC/BCAA, standard chow supplemented with branched-chain amino acids (Val, Leu, Ile); HF, high-fat diet (35% calories from fat); HF/BCAA, HF diet supplemented with branched-chain amino acids. Inset: C3 and C5 acylcarnitines in rats fed on various diets. Data adapted from Newgard et al., 2009. Cell Metabolism 2012 15, 606-614DOI: (10.1016/j.cmet.2012.01.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 3 Schematic Working Model of Potential Crosstalk between Lipids and BCAA in Development of Obesity-Related Insulin Resistance See text for details. “Anaplerosis” refers to repletion or filling up of TCA cycle intermediates via entry points other than acetyl CoA. TG, triglyceride; IMTG, intramyocellular triglyceride; IR, insulin receptor. Cell Metabolism 2012 15, 606-614DOI: (10.1016/j.cmet.2012.01.024) Copyright © 2012 Elsevier Inc. Terms and Conditions