In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies

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In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies Haixia Feng, MS, Pengcheng Xun, MD, PhD, Katharine Pike, PhD, Andrew K. Wills, PhD, Bo L. Chawes, MD, PhD, Hans Bisgaard, MD, DMSc, Wei Cai, MD, PhD, Yanping Wan, MD, Ka He, MD, ScD Journal of Allergy and Clinical Immunology Volume 139, Issue 5, Pages 1508-1517 (May 2017) DOI: 10.1016/j.jaci.2016.06.065 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flowchart of study selection. Journal of Allergy and Clinical Immunology 2017 139, 1508-1517DOI: (10.1016/j.jaci.2016.06.065) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Multivariable-adjusted ORs and 95% CIs (horizontal lines) of asthma. The summary estimates (diamond data markers) were obtained by using a random-effects model. Dots indicate adjusted ORs comparing the highest with the lowest category of or per 10 nmol/L increment in 25(OH)D levels. The size of the shaded square is proportional to the weight of each study. Journal of Allergy and Clinical Immunology 2017 139, 1508-1517DOI: (10.1016/j.jaci.2016.06.065) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Multivariable-adjusted ORs and 95% CIs (horizontal lines) of wheeze. The summary estimates (diamond data markers) were obtained by using a random-effects model. Dots indicate adjusted ORs comparing the highest with the lowest category of or per 10 nmol/L increment in 25(OH)D levels. The size of the shaded square is proportional to the weight of each study. Journal of Allergy and Clinical Immunology 2017 139, 1508-1517DOI: (10.1016/j.jaci.2016.06.065) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Multivariable-adjusted ORs and 95% CIs (horizontal lines) of respiratory tract infections. The summary estimates (diamond data markers) were obtained by using a random-effects model. Dots indicate adjusted ORs comparing the highest with the lowest category of or per 10 nmol/L increment in 25(OH)D levels. The size of the shaded square is proportional to the weight of each study. RTI, Respiratory tract infection. Journal of Allergy and Clinical Immunology 2017 139, 1508-1517DOI: (10.1016/j.jaci.2016.06.065) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions