Cytotoxic effects of cAb-carcinoembryonic antigen 5 (CEA5)::β-lactamase (βL) + 7-(4-carboxybutanamido) cephalosporin mustard (CCM; ♦) combinations on LS174T.

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Presentation transcript:

Cytotoxic effects of cAb-carcinoembryonic antigen 5 (CEA5)::β-lactamase (βL) + 7-(4-carboxybutanamido) cephalosporin mustard (CCM; ♦) combinations on LS174T adenocarcinoma cells. Cytotoxic effects of cAb-carcinoembryonic antigen 5 (CEA5)::β-lactamase (βL) + 7-(4-carboxybutanamido) cephalosporin mustard (CCM; ♦) combinations on LS174T adenocarcinoma cells. A, compared with cells treated with CCM (▪) or phenylenediamine mustard (PDM; ▵) for 1 h without previous conjugate exposure; B, compared with cells that were treated with nonbinding control conjugate cAb-Lys3::βL (▴) before CCM exposure or with saturating amounts of unconjugated cAb-CEA5 (0.1 mg/ml; ▪) before conjugate treatment. Samples were run in triplicate, and SD were <10%. Virna Cortez-Retamozo et al. Cancer Res 2004;64:2853-2857 ©2004 by American Association for Cancer Research