Bifurcation diagrams showing quasi‐steady‐state solutions and simulation of models. Bifurcation diagrams showing quasi‐steady‐state solutions and simulation.

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Bifurcation diagrams showing quasi‐steady‐state solutions and simulation of models. Bifurcation diagrams showing quasi‐steady‐state solutions and simulation of models. (A) Bifurcation diagram for model 1 (toggle switch). When a parameter of the kinetic terms of Rab5 (density of Rab5:GTP, green line) varies as a function of time (here the hydrolysis rate kh,5 increases and other parameters are fixed), then the membrane density of Rab5 decreases until it suddenly drops during the conversion event (green arrow). Opposite to Rab5 switching off, Rab7 (density of Rab7:GTP, blue line) switches on at the same critical parameter value (blue arrow). (B) Bifurcation diagram for model 2 (cut‐out switch; line colours as in (A); the exchange rate ke,5 increases and other parameters are fixed). Here the membrane density of Rab5 increases before dropping during the conversion event (green arrow). For graphical reasons, the parameter values chosen for both bifurcations differ from those of the simulations (see Supplementary information). (C) Numerical simulation of model 1 (solutions plotted in (A)). (D) Numerical simulation of model 2 (solutions plotted in (B)). Perla Del Conte‐Zerial et al. Mol Syst Biol 2008;4:206 © as stated in the article, figure or figure legend