Figure 1 Factors underlying metabolic alterations in osteoarthritis

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Presentation transcript:

Figure 1 Factors underlying metabolic alterations in osteoarthritis Figure 1 | Factors underlying metabolic alterations in osteoarthritis. Poor diet and lifestyle choices can contribute to weight gain and lead to obesity. Ageing, obesity and other co-morbidities associated with osteoarthritis (OA) contribute to metabolic reprogramming in a variety of cells and tissues, leading to inflammaging and cellular senescence, which in turn cause further changes in cellular metabolism in OA. Mobasheri, A. et al. (2017) The role of metabolism in the pathogenesis of osteoarthritis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.50