MEDS 371, Systems Neuroscience Pain System Dr. D. O. Kim

dorsal horn of the spinal cord

CGRP: calcitonin gene related peptide; 5-HT: serotonin

VR-1: vanilloid receptor type 1 capsaicin VR-1: vanilloid receptor type 1

C D synapse of a C-fiber (“C”) on the dendrite (“D”) Kandel Fig. 24-4 synapse of a C-fiber (“C”) on the dendrite (“D”) of a dorsal-horn neuron. small vesicles: glutamate; large vesicles: neuropeptides.

discriminative pain pathways (except face/head) anterolateral system (ALS); spinothalamic tract

section at lumbar spinal cord Purves Brown-Sequard’s syndrome spinal-cord hemisection section at lumbar spinal cord

discriminative pain pathways: face/head trigem gang discriminative pain pathways: face/head trigemino- thalamic tract

trigeminal pathways Haines Fig 8-9 somatosensory cortex principal trigem. sensory nucleus trigemino- thalamic tract pons trigeminal ganglion spinal trigem. tract & nucleus medulla Haines Fig 8-9

affect: n. the conscious subjective aspect of an emotion apart from bodily changes. [Webster’s New Collegiate Dictionary]

Two distinct aspects of the experience of pain thalamic nuclei: midline; anterior; mediodorsal modified from Purves Fig 10-5

thamaic nuclei Netter CM: centromedian; LD: laterodorsal; LP: lateroposterior; MD: mediodorsal; VA: ventral anterior; VL: ventral lateral; VPL: ventral posterolateral; VPM: ventral posteromedial

thalamus hypothalamus cingulate cortex Purves Fig. A-12

Purves Fig. A-10 insula

affective pain pathways; unpleasant quality of pain

enkephalin; dynorphin; endorphin; midbrain periaqueductal gray endogenous opioids: enkephalin; dynorphin; endorphin; in midbrain periaqueductal gray rost. vent. medulla spinal cord

descending control of pain pathways hypothalamus Kandel Fig 24-11

descending control of pain pathways Purves Fig 10-8B

placebo effect a physiological response following the administration of an inert "remedy"

referred pain Kandel Fig. 24-5 Purves

Methods for Rainville et al., 1997 To immerse a hand in painfully hot water (47 °C) for 75 sec; Hypnosis: high or low unpleasantness

Activation of anterior cingulate cortex (ACC) by pain PET imaging of human brains Rainville et al 1997