Biogenesis and functions of circular RNAs

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Biogenesis and functions of circular RNAs Biogenesis and functions of circular RNAs. (A) A gene can be transcribed and spliced into linear and circular RNAs. Note the unique ‘head‐to‐tail’ splice junctions formed by an acceptor splice site at the 5′ end of an exon and a donor site at the 3′ end of a downstream exon. Biogenesis and functions of circular RNAs. (A) A gene can be transcribed and spliced into linear and circular RNAs. Note the unique ‘head‐to‐tail’ splice junctions formed by an acceptor splice site at the 5′ end of an exon and a donor site at the 3′ end of a downstream exon. A demonstrated role for circRNAs is to act as a microRNA sponge. (B) Pictograms of additional plausible options for circRNA function. See main text for details. Matthias W Hentze, and Thomas Preiss EMBO J. 2013;32:923-925 © as stated in the article, figure or figure legend