Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort.

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Presentation transcript:

Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early- osteoarthritis subjects W.E. Van Spil, S.C. Nair, M.B. Kinds, P.J. Emans, W.K.H.A. Hilberdink, P.M.J. Welsing, F.P.J.G. Lafeber Osteoarthritis and Cartilage Volume 23, Issue 1, Pages 48-56 (January 2015) DOI: 10.1016/j.joca.2014.09.003 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Screenshot of KIDA. Small and larger circles are positioned in relation to a framework demarcating the knee joint. The framework and circles are positioned automatically, but their positions can be adjusted manually. JSW is assessed between the small circles aligning the bone-cartilage interface (dotted lines). Osteophyte area is determined outside the larger circles positioned at the corners of the lateral and medial femur and tibia. Bone density is assessed within the small circles, by normalization to an aluminum step wedge (rectangle) included on all radiographs. For details see references 10 and 12. Osteoarthritis and Cartilage 2015 23, 48-56DOI: (10.1016/j.joca.2014.09.003) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Flow diagram of the inclusion procedure of 1002 CHECK subjects (2004 knees) for the current study. Data ranges are presented as mean ± standard deviation for normally distributed variables, as median (25–75% percentiles) for skewed variables, and as proportion (%) per category for discrete variables. BD, bone density; min JSW, minimum joint space width; JSN, joint space narrowing; K&L, Kellgren and Lawrence; OP, osteophyte/osteophytosis; patellofem, patellofemoral. Osteoarthritis and Cartilage 2015 23, 48-56DOI: (10.1016/j.joca.2014.09.003) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions