Volume 14, Issue 6, Pages (June 2014)

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Presentation transcript:

Volume 14, Issue 6, Pages 695-697 (June 2014) Disease Progression in Myelodysplastic Syndromes: Do Mesenchymal Cells Pave the Way? Marc H.G.P. Raaijmakers Cell Stem Cell Volume 14, Issue 6, Pages 695-697 (June 2014) DOI: 10.1016/j.stem.2014.05.010 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 A Hypothetical Model of Heterotypic Reciprocal Signaling Driving Disease Progression in MDS Early genetic events in a primitive hematopoietic cell generate “MDS disease initiating cells” that instruct epigenetic reprogramming of mesenchymal (stem) cells. These reprogrammed mesenchymal cells expand and create a mutagenic field “enabling” clonal expansion and genetic evolution of disease-initiating cells at the cost of normal hematopoiesis. Cell Stem Cell 2014 14, 695-697DOI: (10.1016/j.stem.2014.05.010) Copyright © 2014 Elsevier Inc. Terms and Conditions