Volume 143, Issue 1, Pages 19-22 (July 2012) Mesenchymal Stem Cells and Prostaglandins May Be Critical for Intestinal Wound Repair  Don W. Powell  Gastroenterology  Volume 143, Issue 1, Pages 19-22 (July 2012) DOI: 10.1053/j.gastro.2012.05.013 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 (A) Classic model for intestinal wound healing in which (myo)fibroblasts and macrophages are the primary directors of repair by secreting cytokines, chemokines, growth factors, and matrix molecules. These factors and mediators promote epithelial restitution and proliferation, as well as lamina propria and submucosa matrix deposition, angiogenesis, lymphogenesis, and remodeling. (B) Proposed model of wound healing in which colonic mesenchymal stem cells secrete prostaglandins that orchestrate repair. It is likely that macrophages, myofibroblasts, and blood vessels are also present in the granulation tissue in the proposed model, but they have been omitted for simplicity. It is possible that the prostaglandins act by releasing growth factors and angiogenic factors from myofibroblasts in the granulation tissue of the wound. cMSCs, colonic mesenchymal stem cells; PGs, prostaglandins. Gastroenterology 2012 143, 19-22DOI: (10.1053/j.gastro.2012.05.013) Copyright © 2012 AGA Institute Terms and Conditions