Mesenchymal Stem Cells: Therapeutic Potential for Acute Pancreatitis Günter Schneider, Dieter Saur  Gastroenterology  Volume 140, Issue 3, Pages 779-782 (March 2011) DOI: 10.1053/j.gastro.2011.01.026 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Schematic illustration of the therapeutic effects of engrafted human clonal mesenchymal stem cells (hcMSC) on AP. Acinar cell damage results in premature activation of proenzymes, autodigestion, and acute necroinflammation of the pancreas. An imbalance between proinflammatory cytokine production and the systemic anti-inflammatory response system results in excessive cytokine production, SIRS, and multiorgan failure. hcMSC transplanted 24 hours after induction of AP in an animal model block pancreatic necrosis, inflammation, and proinflammatory cytokine production, most likely because of decreased T-cell infiltration and enhanced recruitment of Treg. Gastroenterology 2011 140, 779-782DOI: (10.1053/j.gastro.2011.01.026) Copyright © 2011 AGA Institute Terms and Conditions