Christopher J. Centeno, MD PM&R

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Clinical Challenges and Opportunities of Mesenchymal Stem Cells in Musculoskeletal Medicine Christopher J. Centeno, MD PM&R Volume 6, Issue 1, Pages 70-77 (January 2014) DOI: 10.1016/j.pmrj.2013.08.612 Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 1 The number of publications listed in the U.S. National Library of Medicine for common stem cell types in the area of cartilage repair. PM&R 2014 6, 70-77DOI: (10.1016/j.pmrj.2013.08.612) Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 2 The number of subjects treated for cartilage repair listed in publications in the U.S. National Library of Medicine or the U.S. Food and Drug Administration clinical trials, by stem cell type. PM&R 2014 6, 70-77DOI: (10.1016/j.pmrj.2013.08.612) Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 3 The number of indexed articles that show that bone marrow or adipose stem cells are superior for cartilage production when the 2 stem cell types are compared head to head in in vitro studies. PM&R 2014 6, 70-77DOI: (10.1016/j.pmrj.2013.08.612) Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 4 Adverse changes in cells increase with time in a culture as biologic potency decreases. PM&R 2014 6, 70-77DOI: (10.1016/j.pmrj.2013.08.612) Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 5 Mesenchymal stem cells can deactivate macrophages that have been previously activated by joint cartilage breakdown products. PM&R 2014 6, 70-77DOI: (10.1016/j.pmrj.2013.08.612) Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 6 The placement of stem cells into a superior labral tear by using ultrasound (not shown) and fluoroscopy to guide the needle along the final delivery path. (courtesy of Ron Hanson, MD, The Centeno-Schultz Clinic) PM&R 2014 6, 70-77DOI: (10.1016/j.pmrj.2013.08.612) Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 7 The delivery of stem cells to the lumbar posterior disk annulus via a novel nitinol catheter. (courtesy of John Schultz, MD, and The Centeno-Schultz Clinic) PM&R 2014 6, 70-77DOI: (10.1016/j.pmrj.2013.08.612) Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions

Figure 8 The placement of stem cells into a nonretracted knee anterior cruciate ligament (ACL) tear, targeting the ACL ligament sheath under direct visualization of the needle by using needle arthroscopy through a second injection site. (courtesy of Ron Hanson, MD, and The Centeno-Schultz Clinic) PM&R 2014 6, 70-77DOI: (10.1016/j.pmrj.2013.08.612) Copyright © 2014 American Academy of Physical Medicine and Rehabilitation Terms and Conditions