Early Cognitive Decline and the Aging Brain - Overview

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Early Cognitive Decline and the Aging Brain - Overview Dan Mungas Friday Harbor Psychometrics Workshop 2015

Acknowledgements Funded in part by Grant R13AG030995 from the National Institute on Aging The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. Friday Harbor Psychometrics Workshop 2015

Brain diseases of aging progress gradually and over many years Alzheimer’s has long been described as having an insidious onset with gradual progression over years Long term slowly progressive effects of cerebrovascular risk factors on the brain and cognition are now well known Framingham Heart Study Friday Harbor Psychometrics Workshop 2015

Model of AD progression Jack et al., 2010 Friday Harbor Psychometrics Workshop 2015

Neuropsychology in age of imaging and biomarkers Important for identifying the earliest clinical changes of diseases of aging Especially important when preventative treatments become available Early diagnosis and treatment will prevent irreversible brain injury and associated disability Friday Harbor Psychometrics Workshop 2015

Unanswered questions about early cognitive decline How can cognitive tests be used to measure and characterize disease progression Are there different patterns of decline in normal cognitive aging and different diseases of aging Which cognitive abilities are most sensitive to cognitive decline associated with which diseases How do different ways of measuring cognitive abilities affect sensitivity to disease Friday Harbor Psychometrics Workshop 2015