Figure 2 Patterns of brain atrophy in Alzheimer disease

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Figure 2 Patterns of brain atrophy in Alzheimer disease Figure 2 | Patterns of brain atrophy in Alzheimer disease. The images show patterns of atrophy on structural neuroimaging observed in various clinical syndromes associated with Alzheimer disease (AD) pathology. In typical amnestic late-onset Alzheimer disease (LOAD), atrophy is first noted in the medial temporal lobes, and gradually spreads to involve the broader temporoparietal and posterior cingulate cortices. Logopenic variant primary progressive aphasia (lvPPA) is characterized by atrophy in the posterior perisylvian region or parietal lobe. For lvPPA, the left (dominant) hemisphere is represented here to indicate that the left-hemispheric cortical areas are predominantly affected. In posterior cortical atrophy (PCA), degeneration of the occipitoparietal and sometimes the posterior temporal lobes is observed. In the behavioural dysexecutive variant of AD, voxel-based morphometric studies reveal temporoparietal atrophy with relative preservation of frontal grey matter. Elahi, F. M. & Miller, B. L. (2017) A clinicopathological approach to the diagnosis of dementia Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.96