Lisa S. Foley, MD, David A. Fullerton, MD, Daine T

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Presentation transcript:

Spinal Cord Ischemia-Reperfusion Injury Induces Erythropoietin Receptor Expression Lisa S. Foley, MD, David A. Fullerton, MD, Daine T. Bennett, MD, Kirsten A. Freeman, MD, Joshua Mares, BA, Marshall T. Bell, MD, Joseph C. Cleveland, MD, Michael J. Weyant, MD, Xianzhong Meng, PhD, MD, Ferenc Puskas, MD, PhD, T. Brett Reece, MD The Annals of Thoracic Surgery Volume 100, Issue 1, Pages 41-46 (July 2015) DOI: 10.1016/j.athoracsur.2015.01.027 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Schematic of erythropoietin (EPO) receptor induction. Schematic depicting ischemic effects on tissue with EPO receptor expression preceding endogenous EPO production and without exogenous administration, ongoing neuronal loss may ensue. (BCL-2 = B-cell lymphoma 2; STAT3 = signal transducer and activator of transcription 3.) The Annals of Thoracic Surgery 2015 100, 41-46DOI: (10.1016/j.athoracsur.2015.01.027) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Light microscopy of neuron culture. Primary spinal cord neurons under contrast light microscopy (microtubule-associated protein 2 [MAP2]-positive neuronal staining; ×20 magnification). The Annals of Thoracic Surgery 2015 100, 41-46DOI: (10.1016/j.athoracsur.2015.01.027) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Ischemia-reperfusion (I/R) induction of (A) beta-common receptor (βcR) and (B) phosphorylated signal transducer and activator of transcription 3 (pSTAT3). The βcR receptor subunit expression and STAT3 activation are increased in all ischemic groups compared with shams. ∗ signifies p <0.05. (EPO = erythropoietin; GAPDH = glyceraldehyde 3-phosphate dehydrogenase.) The Annals of Thoracic Surgery 2015 100, 41-46DOI: (10.1016/j.athoracsur.2015.01.027) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 The beta-common receptor (βcR) subunit induction by oxygen-glucose deprivation (OGD). The OGD induces βcR expression in neurons (5.4 ± 1.35 vs 2.4 ± 0.33, p = 0.03) and astrocytes (4.2 ± 0.35 vs 2.5 ± 0.3, p = 0.01). ∗ signifies p <0.05. The Annals of Thoracic Surgery 2015 100, 41-46DOI: (10.1016/j.athoracsur.2015.01.027) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions