Blood vessel leakiness – how is it controlled?

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Presentation transcript:

Blood vessel leakiness – how is it controlled? Akhil Garg

Blood vessels and diffusion bbc.co.uk

Diseases Inflammation Sepsis (widespread inflammation) Metastasis Viral hemorrhagic infections uic.edu

What makes vessels leaky? drugs could target the factors that make vessels leaky

Angiopoietins and Tie Helmutt, Nature Reviews Molecular Cell Biology 10, 165-177

? 4 angiopoietins Ang-3 and Ang-4 Ang-2 Ang-1 Lungs only? http://www.people.vcu.edu/~wabarton/structures.html Lungs only?

Ang-3 Ang-4

What is the relative binding of each angiopoietin to Tie-2?

Surface Plasmon Resonance (SPR) SPR absorption angle depends on metal surface Metal surface constant: Tie-2 Metal surface variable: Ang-1, Ang-2, Ang-3, Ang-4 etheses.whiterose.ac.uk

SPR Concepts More binding = more change in SPR absorption angle Continuous stream of each angiopoietin

SPR Curves Himanen (2004), Nature Neuroscience 7: 501-509

What is the relative binding of each angiopoietin to Tie-2?

What is the relative binding of each angiopoietin to Tie-2? What is the cellular effect of Ang-4? laughingmantis.com What is the in vivo effect of Ang-4? Wikimedia