FoxO: A New Addition to the ESC Cartel

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FoxO: A New Addition to the ESC Cartel Kevin Andrew Uy Gonzales, Huck-Hui Ng Cell Stem Cell Volume 9, Issue 3, Pages 181-183 (September 2011) DOI: 10.1016/j.stem.2011.08.003 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Models for the Transcriptional Regulatory Network in Human and Mouse ESCs (A) In hESCs, FOXO1 directly upregulates OCT4 and SOX2 expression. (B) Foxo1 and Foxo3 are implicated in the maintenance of the mESC state. Comprehensive determination of the FoxOs' target genes in ESCs would enable a global understanding of their integration into the pluripotency network, as well as provide new insights into species-specific circuitries. Cell Stem Cell 2011 9, 181-183DOI: (10.1016/j.stem.2011.08.003) Copyright © 2011 Elsevier Inc. Terms and Conditions