Scott J. Bultman, Christian Jobin Cell Host & Microbe

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Microbial-Derived Butyrate: An Oncometabolite or Tumor-Suppressive Metabolite? Scott J. Bultman, Christian Jobin Cell Host & Microbe Volume 16, Issue 2, Pages 143-145 (August 2014) DOI: 10.1016/j.chom.2014.07.011 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Microbiota-Derived Metabolism of Carbohydrates Promotes Polyp Frequency in the Intestine Butyrate-producing bacteria such as Clostridiaceae, Lachnospiraceae, and Ruminococcaceae biotransform carbohydrates into butyrate, which, in the context of cancer-initiated colonocytes such as those observed in the epithelium of ApcMin/+;Msh2−/− mice, foster cellular proliferation and polyp formation. The microbiota of ApcMin/+;Msh2−/− mice exposed to low-carbohydrate diet or antibiotics is impaired in its metabolic capacitiy and butyrate formation, thereby preventing cancer-initiated colonocyte proliferation and cancer progression. Cell Host & Microbe 2014 16, 143-145DOI: (10.1016/j.chom.2014.07.011) Copyright © 2014 Elsevier Inc. Terms and Conditions