The ABCs of Nitric Oxide in the Skin

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Presentation transcript:

The ABCs of Nitric Oxide in the Skin

NO Is a Potential Therapeutic Option

Antimicrobial Properties of NO

Antimicrobial Properties of NO (cont)

Cytoprotective Properties

Immunomodulatory Effects

Pathophysiology of Acne

Pathophysiology of Acne

Pathophysiology of Acne (cont)

Inflammatory Processes in Acne

Activation of the NLRP3 Inflammasome

Th1 and Th17 Immune Responses in Acne

P acnes and Inflammation

The NLRP3 Inflammasome and Acne

NO in Acne

Challenges in the Development of an NO-Based Acne Treatment

SB204 Study Design

SB204 Efficacy Data

SB204 Safety Data

Concluding Remarks

Abbreviations