A Crystal-Clear Interaction: Relating Neuroligin/Neurexin Complex Structure to Function at the Synapse Joshua N. Levinson, Alaa El-Husseini Neuron

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A Crystal-Clear Interaction: Relating Neuroligin/Neurexin Complex Structure to Function at the Synapse Joshua N. Levinson, Alaa El-Husseini Neuron Volume 56, Issue 6, Pages 937-939 (December 2007) DOI: 10.1016/j.neuron.2007.12.003 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Neuroligin/Neurexin Complex at the Synapse (A) Neuroligins (blue) dimerize through a four-helix bundle, which allows two neurexin molecules (orange) to bind the neuroligin dimer. Presence of an insert at splice site B in neuroligins (red) diminishes binding of neuroligins to α-neurexins. (B) Mutations associated with autism are predicted to disrupt neuroligin dimerization and reduce the affinity of neuroligins for neurexins. Neuron 2007 56, 937-939DOI: (10.1016/j.neuron.2007.12.003) Copyright © 2007 Elsevier Inc. Terms and Conditions