Volume 151, Issue 2, Pages 518-519 (February 2017) Characterizing Systemic Immune Dysfunction Syndrome to Fill in the Gaps of SEPSIS-2 and SEPSIS-3 Definitions  Jesús F. Bermejo-Martin, MD, PhD, Eduardo Tamayo, MD, PhD, David Andaluz-Ojeda, MD, PhD, Marta Martín-Fernández, MSc, Raquel Almansa, PhD  CHEST  Volume 151, Issue 2, Pages 518-519 (February 2017) DOI: 10.1016/j.chest.2016.11.047 Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 1 SIDS would indicate a potential complicated outcome in patients experiencing an infection. Left, Gaps not covered by SEPSIS-2 or SEPSIS-3 definitions. A = presence of infection with organ failure (Sequential Organ Failure Assessment score ≥ 2) but with no SIRS. B = presence of infection with no organ failure at clinical diagnosis, with no SIRS, but at risk of complications based on the immunologic profile (SIDS). C = presence of infection with SIRS and no organ failure at clinical diagnosis but at risk of complications based on the immunologic profile (SIDS). Right, The presence of SIDS + infection would define sepsis. SIDS = systemic immune dysfunction syndrome; SIRS = systemic inflammatory response syndrome. CHEST 2017 151, 518-519DOI: (10.1016/j.chest.2016.11.047) Copyright © 2016 American College of Chest Physicians Terms and Conditions