CD39: A new surface marker of mouse regulatory γδ T cells

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Presentation transcript:

CD39: A new surface marker of mouse regulatory γδ T cells Atsushi Otsuka, MD, PhD, Sho Hanakawa, MS, Yoshiki Miyachi, MD, PhD, Kenji Kabashima, MD, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 6, Pages 1448-1451 (December 2013) DOI: 10.1016/j.jaci.2013.05.037 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The expression and suppressive activity of CD39+ γδ T cells. A, The expression of CD39, CD27, CD122, CD25, and programmed death-1 (PD-1) on Thy1.2+ γδTCR+ γδ T cells from axillary and inguinal lymph nodes. B, The expression of Foxp3 on CD39+ γδ T cells. C, The proliferative activity with CD39−, CD39+ γδ T cells, or Treg cells. D, The proliferative activity in the absence of DCs. E, The mRNA level of IL-10 and IFN-γ of CD39+, CD39− γδ T, and Treg cells. F, The proliferative activity with CD39+γδ T cells from wild-type or IL-10 knockout (IL10−/−) mice. All data are presented as the mean ± SD (n = 5) and are representative of 3 experiments. *P < .05 (Wilcoxon signed-rank test) versus corresponding groups. Journal of Allergy and Clinical Immunology 2013 132, 1448-1451DOI: (10.1016/j.jaci.2013.05.037) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The expression and suppressive activity of in vitro–induced CD39+ γδ T cells. A, The expression of CD39 on γδ T cells before (left panel) and after (right panel) in vitro stimulation. B, The expression of CD4, CD8, CD27, CD122, Foxp3, and CD25 on CD39+γδ T cells. C, The proliferative activity with in vitro–induced CD39+ γδ T cells. D, The time course of the contact hypersensitivity reaction with adoptive cell transfer of CD4+ or CD39+ γδ T cells. All data are presented as the mean ± SD (n = 5) and are representative of 3 experiments. *P < .05 (Wilcoxon signed-rank test) versus corresponding groups. Journal of Allergy and Clinical Immunology 2013 132, 1448-1451DOI: (10.1016/j.jaci.2013.05.037) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions