Successful Hemostasis During a Major Orthopedic Operation by Using Recombinant Activated Factor VII in a Patient With Severe Hemophilia A and a Potent Inhibitor  AENGUS S. O'MARCAIGH, M.D., BETTY J. SCHMALZ, R.N., WILLIAM J. SHAUGHNESSY, M.D., GERALD S. GILCHRIST, M.D.  Mayo Clinic Proceedings  Volume 69, Issue 7, Pages 641-644 (July 1994) DOI: 10.1016/S0025-6196(12)61340-8 Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 A, Preoperative roentgenogram of right knee of 16-year-old boy, showing severe hemophiliac arthropathy and lateral dislocation of patella. B, Postoperative roentgenogram, showing internal fixation and shortening osteotomy of distal femur. Mayo Clinic Proceedings 1994 69, 641-644DOI: (10.1016/S0025-6196(12)61340-8) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Response of factor VII activity level, prothrombin time (PT), and activated partial thromboplastin time (APTT) to administration of recombinant activated factor VII (rFVIIa). PT and APTT were determined immediately before each rFVIIa dose. Activity of factor VII was measured immediately before and 10 minutes after each rFVIIa dose. Mayo Clinic Proceedings 1994 69, 641-644DOI: (10.1016/S0025-6196(12)61340-8) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions