A presenilin 1 mutation in the first case of Alzheimer's disease

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A presenilin 1 mutation in the first case of Alzheimer's disease Ulrich Müller, Pia Winter, Manuel B Graeber The Lancet Neurology Volume 12, Issue 2, Pages 129-130 (February 2013) DOI: 10.1016/S1474-4422(12)70307-1 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure Sequence chromatograms of 28 bp of exon 6 of PSEN1 in DNA extracted from brain samples of Auguste Deter Sequencing detected a c.526T→C substitution. Both the sequence of the forward DNA strand (A) and the sequence of the reverse strand (B) are shown. The resulting aminoacid change, Phe176Leu, is indicated (F/L). The slight compressions at positions c.533 and c.537 were resolved on the reverse strand. The Lancet Neurology 2013 12, 129-130DOI: (10.1016/S1474-4422(12)70307-1) Copyright © 2013 Elsevier Ltd Terms and Conditions