Figure 6 Factors modulating SCN5A gene expression

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Figure 6 Factors modulating SCN5A gene expression Figure 6 | Factors modulating SCN5A gene expression. H2O2 (and possibly plakophilin 2; PKP2) promotes the nuclear translocation of catenin-β1 (Refs 108,120). Transcription factor 4 (TCF4) and catenin-β1 form a complex that interacts with a promoter region of SCN5A, suppressing the expression of this gene119. The microRNAs miR-219 and miR-200 regulate the post-transcriptional expression of SCN5A118. The T-box transcription factors TBX3 and TBX5 interact with an enhancer region in SCN10A and SCN5A loci, and regulate the expression of both genes115. The transcription factors GATA4 and GATA5 synergistically activate the expression of SCN5A through promoter binding sites116. ROS, reactive oxygen species. Moncayo-Arlandi, J. & Brugada, R. (2017) Unmasking the molecular link between arrhythmogenic cardiomyopathy and Brugada syndrome Nat. Rev. Cardiol. doi:10.1038/nrcardio.2017.103