building the primary hub for Life Science Expert Guidance

What is N-Site What is N-Site A portal for specialist guidance on critical matters for companies operating within Life Science An essential resource: free for start-ups and academics and unambiguous value for members A resource that responds to and shares insight on key issues for its subscribing members A place that consolidates leading expertise beyond a single firm N-Site currently covers legal, IP and tax guidance but will expand across a wide range of specialisms in response to companies’ needs Underlying Principles High quality guidance from leading specialists in Life Science Businesses can find it difficult to identify and navigate to the right expert in a particular field - N-Site can address this Access to quality contextual knowledge will allow business to make much quicker and better buying decisions It will also expedite understanding of risks and opportunities at a much earlier stage It will allow businesses to engage advisers for application on a much more informed basis N-Site endeavours to make complex matters much more simple

Tax Guidance Notes (GNTs) Employment Tax & Share Schemes PAYE Settlement Agreements (PSAs) Employment Status Academic Spin-Out Relief EMI Valuations Termination Payments EMI Share Options Corporation Tax Deductions for Employee Share Schemes Investment, EIS & VCT Investors’ Relief Enterprise Investment Scheme (EIS) Essentials Seed Enterprise Investment Scheme Essentials EIS Administration EIS Business Angel Relief Entrepreneurs’ Relief Transactions Licensing Deferred Consideration Substantial Shareholdings Exemption Tax Efficient Divestment Demergers Retention of Losses Post Merger Patent Box Patent Box R&D Fraction – As Applied to Life Sciences International Tax Summary of US Tax Reform Implementation of BEPS PFICs Double Tax Treaties Tax Residence Tax Implications of Brexit on the Pharmaceutical Industry Diverted Profits Tax Setting up in the US BEPS Overview Intercompany Agreements for Transfer Pricing Permanent Establishments Benefits of Incorporating in the UK Expansion into New Territories UK the Case for Inward Investment Transfer Pricing Essentials VAT & Duty Recovery of VAT on Fundraising VAT – Supply Chain R&D Tax Incentives Qualifying Expenditure – SME Qualifying Expenditure – RDEC Subsidised R&D – for Claimants Under the SME Scheme R&D Incentives Chart of Accounts Going Concern Requirement for SME R&D Incentives BIS Guidelines for R&D Qualifying Direct and Indirect Activities for R&D Tax Incentives SME R&D Regime Essentials Sub-contract R&D and Externally Provided Workers SME R&D Tax Credit and RDEC Comparison Enhancing R&D Incentives on Clinical Trials RDEC – Essentials Tax Compliance Tax Framework and Strategy Compliance Best Practice for Development Companies Compliance Essentials Tax Model Bioscience Explained to Support Tax Returns Corporation Tax Loss Relief Reform

Legal Guidance Notes (GNLs) Agreements & Transactions Research, development and collaboration agreements Drafting commercial agreements: Key points Licensing patents: Key points 1 Licensing patents: Key points 2 Taking security over patents Regulations and Authorisations Medical devices regulation: The new rules Medical devices regulation: The current rules Regulations of medicine advertising and promotion Marketing authorisations for medicines: Key points Corporate Setting up a company 1 Setting up a company 2 Setting up a company 3 Intellectual Property Introduction to patents and patent infringement Supplementary protection certificates: Basics Employment Restrictive covenants: Keeping your information safe

Subscription Subscription – Annual site licence (unrestricted use across the company). Alternatively, companies more interested in specific areas of guidance can opt for a licence to part of the site. The unit cost for the first licence is £250 which will allow a single user access to a single field. The licence can be extended at a cost of £125 for each additional user or field. Any company with annual subscription fees of at least £2,000 receives a Guidance Note Credit (thereafter an additional guidance note credit is awarded for each £2,000 in the annual subscription). All companies are welcome to enjoy a trial period of three months prior to becoming a paying member. Start-ups and Academics        We are pleased to make these resources available free of charge to: Academics looking to establish a new commercial venture Employees of an early stage company that fulfils both of the following conditions: Less than £2m annual sales Less than £5m funds raised (in aggregate) Headcount Annual licence 1-25 £2,000 26-100 £4,000 >100 £6,000