History of the Rochester Epidemiology Project: Half a Century of Medical Records Linkage in a US Population  Walter A. Rocca, MD, MPH, Barbara P. Yawn,

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History of the Rochester Epidemiology Project: Half a Century of Medical Records Linkage in a US Population  Walter A. Rocca, MD, MPH, Barbara P. Yawn, MD, MSc, Jennifer L. St. Sauver, PhD, MPH, Brandon R. Grossardt, MS, L. Joseph Melton, MD, MPH  Mayo Clinic Proceedings  Volume 87, Issue 12, Pages 1202-1213 (December 2012) DOI: 10.1016/j.mayocp.2012.08.012 Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 1 A, The father, W. W. Mayo (1819-1911, center), and the 2 Mayo brothers, W. J. Mayo (1861-1939, right) and C. H. Mayo (1865-1939, left). B, Leather-bound ledgers used before 1907. C, H. S. Plummer (1874-1936). D, The new medical record introduced by Dr Plummer in 1907 to assemble forms for each patient into a dossier (paper file). Photographs courtesy of the Mayo Historical Unit, Mayo Clinic, Rochester, Minnesota. Mayo Clinic Proceedings 2012 87, 1202-1213DOI: (10.1016/j.mayocp.2012.08.012) Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 2 A, Mabel Root (1878-1981), secretary to Dr Plummer. B, Index card listing patients seen at Mayo Clinic for hypothyroidism (organ = thyroid; disease = hypothyroidism). C, J. Berkson (1899-1982). D, A Hollerith punch card used for mechanical data processing. Photographs courtesy of the Mayo Historical Unit, Mayo Clinic, Rochester, Minnesota. Mayo Clinic Proceedings 2012 87, 1202-1213DOI: (10.1016/j.mayocp.2012.08.012) Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 3 A, L. T. Kurland (1921-2001), founder of the Rochester Epidemiology Project. B, L. J. Melton III (1944-). C, Current logo of the Rochester Epidemiology Project. Photographs courtesy of the Mayo Historical Unit, Mayo Clinic, Rochester, Minnesota. Mayo Clinic Proceedings 2012 87, 1202-1213DOI: (10.1016/j.mayocp.2012.08.012) Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 4 Scheme of the steps involved in linking medical records, indexing diagnoses and other data, and retrieving medical records for a research study. Mayo Clinic Proceedings 2012 87, 1202-1213DOI: (10.1016/j.mayocp.2012.08.012) Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions