Posttranslational regulation of ETV5 and c-JUN in neurons.

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Posttranslational regulation of ETV5 and c-JUN in neurons. Posttranslational regulation of ETV5 and c-JUN in neurons. (A) Western blots of E18.5 mouse brain lysates after immunoprecipitation (IP) with anti-FLAG M2 beads. (B) Western blots of cortical neurons cultured for 2 d and then stimulated with 100 ng/mL BDNF with or without 1 μM ERK inhibitor (ERKi) for 2 h. mRNA expression was determined by quantitative RT-PCR. (C) Western blots of cortical neurons cultured for 14 d and then stimulated with 100 μM PTX with or without 1 μM ERKi for 5 min. (D) Western blots of cortical neurons infected with adeno-associated viruses expressing WT or mutant COP1. Results in A–D are representative of three independent experiments. Kim Newton et al. PNAS 2018;115:44:11244-11249 ©2018 by National Academy of Sciences